Lange 20062017 Name: Dr. Andreas Lange

Status: Postdoc

Email: andreas.lange[a]uni-muenster.de

Tel.: +49-(0)251-83-21086

Room: 205


Curriculum

  • since 01/2020: Safety manager for laboratories at IEB
  • 08/2019 to 10/2019: Visiting Scientist at BMC Uppsala, Prof. Ylva Ivarssons' lab (EMBO short-term 8268)
  • since 09/2018: Project manager according to the gene technology act (§ 15 GenTSV)
  • since 10/2016: Postdoc at the Institute for Evolution and Biodiversity, University of Muenster
  • 10/2015 - 09/2016: Postdoc in the group of Prof. Dr. Frank Boeckler
  • 07/2010 - 10/2015: PhD student in the group of Prof. Dr. Frank Boeckler, Molecular Design & Pharm. Biophysics, Eberhard-Karls-University Tuebingen; Title: "Using Theoretical and Biophysical Techniques to Study the Applicability of Halogen Bonds in Molecular Design"
  • 05/2008 - 05/2010: MSc Chemistry, Ludwig-Maximilians-University, Munich; Title: "Towards Broader Recognition of Halogen Bonds in Drug Design - Quantum Mechanical Calculations on the Interaction of Amino Acid Models with Selected Ligand Systems"
  • 10/2004 - 02/2008: BSc Chemistry and Biochemistry, Ludwig-Maximilians-University, Munich

Scholarships

  • EMBO Short-Term Fellowship Number 8268: Using proteomic phage display to characterize the functionality of de novo genes from Drosophila melanogaster

Research interests

  • Structure prediction of de novo proteins (Quick2D, Quark, MD)
  • Purification and characterization of de novo proteins (structure and function)
  • Structural investigation of proteins through CD, NMR,
  • Theoretical and experimental study of protein-protein (PhageDisplay, together with Ivarsson lab, Uppsala)

Publications

2020

  • Structure and Function of Naturally Evolved de novo Proteins
    Bornberg-Bauer, E., Hlouchova, K., Lange A.
    COSB, 2020, in Revision
  • Structural and functional characterization of a putative de novo evolved gene essential for male fertility in Drosophila
    Lange A. , Prajal PH, Heames B , Findlay GD, Bornberg-Bauer E
    submitted, 2020
2019
  • Small Molecule Intervention at the Dimerization Interface of Survivin by Novel Rigidized Scaffolds
    Tamer Ibrahim, Christoph Ernst, Andreas Lange, Susanne Hennig, Frank M. Boeckler, Drug Design, Development and Therapy, 2019:13 4247–4263
  • Scaffold Effects on Halogen Bonding Strength
    Andreas Lange, Johannes Heidrich, Markus O. Zimmermann, Thomas E. Exner, Frank M. Boeckler
    J. Chem. Inf. Model., 2019, 59 (2), pp 885–894
2017
  • Tri- and Tetra-substituted Pyridinylimidazoles as Covalent Inhibitors of c-Jun N-Terminal Kinase 3
    Felix Muth*, Ahmed El-Gokha*, Francesco Ansideri, Michael Eitel, Eva Döring, Adrian Sievers-Engler, Andreas Lange, Frank M. Boeckler, Michael Laemmerhofer, Pierre Koch, and Stefan A. Laufer
    J. Med. Chem, 2017, 60 (2), pp 594–607
2016
  • Using Surface Scans for the Evaluation of Halogen Bonds toward the Side Chains of Aspartate, Asparagine, Glutamate, and Glutamine
    Markus O. Zimmermann, Andreas Lange, Stefan Zahn, Thomas E. Exner & Frank M. Boeckler
    J. Chem. Inf. Model., 2016, 56 (7), pp 1373–1383
  • Fluorescence polarization-based assays for detecting compounds binding to inactive JNK3 and p38alpha MAP kinase
    Francesco Ansideri, Andreas Lange, Ahmed El-Gokha, Frank M. Boeckler & Pierre Koch
    Anal. Biochem., 2016, 503, pp 28 - 40
2015
  • Targeting the Gatekeeper MET146 of C-Jun N-terminal Kinase 3 (JNK3) Induces a Bivalent Halogen / Chalcogen Bond
    Andreas Lange*, Marcel B. Guenther*, Felix M. Büttner, Markus O. Zimmermann , Johannes Heidrich, Susanne Hennig, Stefan Zahn, Christoph Schall, Adrian Sievers-Engler, Francesco Ansideri, Pierre Koch, Michael Laemmerhofer, Thilo Stehle, Stefan A. Laufer & Frank M. Boeckler
    J. Am. Chem. Soc., 2015, 137 (46), pp 14640–14652
  • Evaluating the Potential of Halogen Bonding in Molecular Design: Automated Scaffold Decoration Using the New Scoring Function XBScore
    Markus O. Zimmermann, Andreas Lange, and Frank Michael Boeckler
    J. Chem. Inf. Model, 2015, 55 (3), pp 687–699
2014
  • Halogen-enriched fragment libraries as chemical probes for harnessing halogen bonding in fragment-based lead discovery
    Markus O. Zimmermann*, Andreas Lange*, Rainer Wilcken*, Markus B. Cieslik, Thomas E. Exner, Andreas C. Joerger, Pierre Koch, Frank M Boeckler
    Fut. Med. Chem., 2014, 6 (6), pp 617-639 (Perspective)
  • Machine Learning Estimates of Natural Product Conformational Energies
    Matthias Rupp, Matthias R. Bauer, Rainer Wilcken, Andreas Lange, Michael Reutlinger, Frank M. Boeckler, Gisbert Schneider
    PLOS Computational Biology, 2014, 10 (1)
2013
  • Targeting histidine sidechains in molecular design through nitrogen-halogen bonds
    Andreas Lange, Markus O. Zimmermann, Rainer Wilcken, Stefan Zahn and Frank M. Boeckler
    J. Chem. Inf. Model., 2013, 53 (12), pp 3178–3189
  • Principles and Applications of Halogen Bonding in Medicinal Chemistry and Chemical Biology
    Rainer Wilcken*, Markus O. Zimmermann*, Andreas Lange*, Andreas C. Joerger and Frank M. Boeckler
    J. Med. Chem., 2013, 56 (4), pp 1363–1388 (Perspective)
2012
  • Using halogen bonds to address the protein backbone: a systematic evaluation
    Rainer Wilcken, Markus O. Zimmermann, Andreas Lange, Stefan Zahn, Frank M. Boeckler
    J Comput Aided Mol Des, 2012, 26 (8), pp 935 - 945
2011
  • Addressing Methionine in Molecular Design through Directed Sulfur–Halogen Bonds
    Rainer Wilcken, Markus O. Zimmermann, Andreas Lange, Stefan Zahn, Barbara Kirchner, Frank M. Boeckler
    J. Chem. Theory Comput., 2011, 7 (7), pp 2307–2315

    *authors contributed equally