Name:
Moore, Andrew
Status:
Postdoc
Email:
a.moore@uni-muenster.de
Tel.:
+49-(0)251-83-
Room:
Curriculum
- October 2011- January 2013: Postdoctoral fellow
- 2007 - 2011: Ph.D Student, Evolutionary Bioinformatics
- 2006 - 2007: Diplom (equiv. MSc) in the group of Evolutionary Bioinformatics, IEB
-
2004: Visiting student, Faculty of Science, University of British Columbia, Vancouver, Canada
2001-2005: Studies in Biology and Computer Science, WWU Muenster
Awards
WWU final year scholarship for outstanding young researchers
Teaching
- Bioinformatics I (WS 08/09, WS 09/10, WS 10/11)
- Advanced Programming for Bioinformatics (SS 09)
- Supervision support of students at BSc and MSc level (07/08/09)
Research Interests
- Modularity of protein evolution
The linear order of domains that makes up a protein is referred to as a domain arrangement or a domain architecture. The analysis of protein domain arrangements across species indicates that functional novelty is achieved by the recombination of existing domains, as opposed to the invention of new domains, coining the concept of modular protein evolution. We study the evolution of proteomes by quantifying the nature and rates of modular re-arrangement events and the functional impact these events have.
- Development of domain-centric tools for protein anaylsis
Tools / Software
-
DoMosaics: A powerful Java program for domain-based analysis and visualization of proteins
- xdomsuite: a Ruby API for domain data
- RTree: a Ruby API for tree traversal
- RadScan: a Java-based cli-utility for conducting architecture-based similarity searches
- GoZapper: A program for visualization of Gene ontology associations
- PfamScanner: a Java-based cli-utility for running HMMSCAN. Includes post-processing options (e.g. overlap resolution, merge split hits, collapse repeats). Returns xdom format.
Publications
-
A. D. Moore, A. Held, N. Terrapon, J. Weiner, and E. Bornberg-Bauer
DoMosaics: Software for domain arrangement visualization and domain-centric analysis of proteins.
Bioinformatics, 2014 Jan 15;30(2):282-3. doi: 10.1093/bioinformatics/btt640. Epub 2013 Nov 12., 2014
[Online access]
- N. Terrapon*, J. Weiner*, S. Grath A. D. Moore, and E. Bornberg-Bauer
Rapid similarity search of proteins using alignments of domain arrangements
Bioinformatics, 30, 274-281, 2014
[Online access]
- A. D. Moore, S. Grath, A. Schüler, A. K. Huylmans, and E. Bornberg-Bauer
Quantification and Functional Analysis of Modular Protein Evolution in a Dense Phylogenetic Tree
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1834, (5): 898–907, 2013
[Online access]
- Journal articles
A.R. Kersting, E. Bornberg-Bauser, A. D. Moore*, and S. Grath*
Dynamics and adaptive benefits of protein domain emergence and arrangements during plant genome evolution
* corresponding authors
Genome Biol Evol, in press, 2012
- A. D. Moore and E. Bornberg-Bauer
The Dynamics and Evolutionary Potential of Domain Loss and Emergence
Molecular Biology and Evolution 29(2): 787-796, 2012
- The Nasonia Genome Working Group
Functional and evolutionary insights from the genomes of three parasitoid Nasonia species
Science, 327:5963, 2010
- L. Wissler; E. Dattolo; A. D. Moore; T. B. H. Reusch; J. L. Olsen; M. Migliaccio; E. Bornberg-Bauer; G. Procaccini
Dr. Zompo: an online data repository for Zostera marina and Posidonia oceanica ESTs
Database 2009; doi: 10.1093/database/bap009, 2009
- A. D. Moore*, A. K Bjoerklund*, D. Ekman, E. Bornberg-Bauer and A. Elofsson
Arrangements in the Modular Evolution of Proteins
* these authors contributed equally to this work
Trends in Biochemical Sciences, 33(09): 444-51, 2008
- J. Weiner 3rd, A. D. Moore, E. Bornberg-Bauer
Just how versatile are domains?
BMC Evolutionary Biology, 8:285, 2008
Book chapters
- A. D. Moore and E. Bornberg-Bauer
Protein domains as evolutionary units
in: Evolutionary Genomics and Systems Biology, Ed. G. Caetano-Anollés (2010)
John Wiley & Sons
- Conference proceedings / published abstracts
A. D. Moore and E. Bornberg-Bauer
Footprints of modular evolution in a dense taxonomic clade
GCB 2012 Highlight Abstracts, Jena (Germany), 2012
- N. Terrapon, S. Grath, J. Weiner, A. D. Moore, and E. Bornberg-Bauer
Fast Homology Search Using Domain-Architecture Alignment. Journées Ouvertes en Biologie, Informatique et Mathématiques (JOBIM), Rennes (France), 2012
Attended conferences & workshops; conference contributions
- German Conference on Bioinformatics
highlight paper selected as oral presentation
Jena (Germany), September 19-22, 2012
- 5th Annual Genomics Symposium
poster abstract selected as oral presentation; presented by Sonja Grath
Kansas City (USA), June 9-12, 2011
- Interdisciplinary Graduate Students Symposium evolution across fields
Münster (GER), February 17-18, 2011
- 3rd Annual Arthropod Genomics Symposium
Kansas City (USA), June 11-14, 2009
Posters:
AnGSTD
Modular Evolution
- Cologne Spring Meeting 2009: The variable genome
Cologne (GER), Mar 18-20, 2009
Sponsored by: SFB680, Fritz-Thyssen-Stiftung, Fonds der Chemischen Industrie, and others
- Evolution across scales
Potsdam (GER), May 26-28, 2008
Sponsered by The Volkswagen Foundation
- Advanced Protein Domain Analysis Training Workshop
Lyon (FRA), May 18-20, 2008
Sponsered by Embrace
- SMBE 2007
Halifax (CDN), June 24-28, 2007