Curriculum

• October 2011- January 2013: Postdoctoral fellow
• 2007 - 2011: Ph.D Student, Evolutionary Bioinformatics
• 2006 - 2007: Diplom (equiv. MSc) in the group of Evolutionary Bioinformatics, IEB
• 2004: Visiting student, Faculty of Science, University of British Columbia, Vancouver, Canada
  2001-2005: Studies in Biology and Computer Science, WWU Muenster

WWU final year scholarship for outstanding young researchers

• Bioinformatics I (WS 08/09, WS 09/10, WS 10/11)
• Advanced Programming for Bioinformatics (SS 09)
• Supervision support of students at BSc and MSc level (07/08/09)

• Modularity of protein evolution The linear order of domains that makes up a protein is referred to as a domain arrangement or a domain architecture. The analysis of protein domain arrangements across species indicates that functional novelty is achieved by the recombination of existing domains, as opposed to the invention of new domains, coining the concept of modular protein evolution. We study the evolution of proteomes by quantifying the nature and rates of modular re-arrangement events and the functional impact these events have.
• Development of domain-centric tools for protein anaylsis

• DoMosaics: A powerful Java program for domain-based analysis and visualization of proteins
• xdomsuite: a Ruby API for domain data
• RTree: a Ruby API for tree traversal
• RadScan: a Java-based cli-utility for conducting architecture-based similarity searches
• GoZapper: A program for visualization of Gene ontology associations
• PfamScanner: a Java-based cli-utility for running HMMSCAN. Includes post-processing options (e.g. overlap resolution, merge split hits, collapse repeats). Returns xdom format.

1. A. D. Moore, A. Held, N. Terrapon, J. Weiner, and E. Bornberg-Bauer
   DoMosaics: Software for domain arrangement visualization and domain-centric analysis of proteins.
   Bioinformatics, 2014 Jan 15;30(2):282-3. doi: 10.1093/bioinformatics/btt640. Epub 2013 Nov 12., 2014
   [Online access]
2. N. Terrapon*, J. Weiner*, S. Grath A. D. Moore, and E. Bornberg-Bauer
   Rapid similarity search of proteins using alignments of domain arrangements
   Bioinformatics, 30, 274-281, 2014
   [Online access]
3. A. D. Moore, S. Grath, A. Schüler, A. K. Huylmans, and E. Bornberg-Bauer
   Quantification and Functional Analysis of Modular Protein Evolution in a Dense Phylogenetic Tree
   Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1834, (5): 898–907, 2013
   [Online access]
4. Journal articles
   A.R. Kersting, E. Bornberg-Bauser, A. D. Moore*, and S. Grath*
   Dynamics and adaptive benefits of protein domain emergence and arrangements during plant genome evolution
   * corresponding authors
   Genome Biol Evol, in press, 2012
5. A. D. Moore and E. Bornberg-Bauer
   The Dynamics and Evolutionary Potential of Domain Loss and Emergence
   Molecular Biology and Evolution 29(2): 787-796, 2012
6. The Nasonia Genome Working Group
   Functional and evolutionary insights from the genomes of three parasitoid Nasonia species
   Science, 327:5963, 2010
7. L. Wissler; E. Dattolo; A. D. Moore; T. B. H. Reusch; J. L. Olsen; M. Migliaccio; E. Bornberg-Bauer; G. Procaccini
   Dr. Zompo: an online data repository for Zostera marina and Posidonia oceanica ESTs
   Database 2009; doi: 10.1093/database/bap009, 2009
8. A. D. Moore*, A. K Bjoerklund*, D. Ekman, E. Bornberg-Bauer and A. Elofsson
   Arrangements in the Modular Evolution of Proteins
   * these authors contributed equally to this work
   Trends in Biochemical Sciences, 33(09): 444-51, 2008
9. J. Weiner 3rd, A. D. Moore, E. Bornberg-Bauer
   Just how versatile are domains?
   BMC Evolutionary Biology, 8:285, 2008

Book chapters

1. A. D. Moore and E. Bornberg-Bauer
   Protein domains as evolutionary units
   in: Evolutionary Genomics and Systems Biology, Ed. G. Caetano-Anollés (2010)
   John Wiley & Sons
   
2. Conference proceedings / published abstracts
   A. D. Moore and E. Bornberg-Bauer
   Footprints of modular evolution in a dense taxonomic clade
   GCB 2012 Highlight Abstracts, Jena (Germany), 2012
3. N. Terrapon, S. Grath, J. Weiner, A. D. Moore, and E. Bornberg-Bauer
   Fast Homology Search Using Domain-Architecture Alignment. Journées Ouvertes en Biologie, Informatique et Mathématiques (JOBIM), Rennes (France), 2012

• German Conference on Bioinformatics
  highlight paper selected as oral presentation
  Jena (Germany), September 19-22, 2012
• 5th Annual Genomics Symposium
  poster abstract selected as oral presentation; presented by Sonja Grath
  Kansas City (USA), June 9-12, 2011
• Interdisciplinary Graduate Students Symposium evolution across fields
  Münster (GER), February 17-18, 2011
• 3rd Annual Arthropod Genomics Symposium
  Kansas City (USA), June 11-14, 2009
  Posters:
  AnGSTD
  Modular Evolution
• Cologne Spring Meeting 2009: The variable genome
  Cologne (GER), Mar 18-20, 2009
  Sponsored by: SFB680, Fritz-Thyssen-Stiftung, Fonds der Chemischen Industrie, and others
• Evolution across scales
  Potsdam (GER), May 26-28, 2008
  Sponsered by The Volkswagen Foundation
• Advanced Protein Domain Analysis Training Workshop
  Lyon (FRA), May 18-20, 2008
  Sponsered by Embrace
• SMBE 2007
  Halifax (CDN), June 24-28, 2007