Tobias Portrait Name: Sikosek, Tobias

Status: Postdoc


Tel.: +49-(0)251-83-21086

Room: 205

  • evolution of protein structure and function
  • evolution by gene duplication (neo-/subfunctionalisation)
  • evolutionary computer simulations, lattice proteins
  • protein stability/disorder/folding
  • structural bioinformatics
  • catalytic promiscuity and experimental evolution of enzymes
  • evolution of miRNAs
  • 2000-2006: studies in biology, philosophy and computer sciences at the University of Muenster; focus on practical and theoretical evolutionary biology,  molecular cell biology, and bioinformatics.
  • 2004-2005: study abroad year at the University of Auckland, New Zealand ; courses in microbiology, immunology, biochemistry, and ecology.
  • 2006-2007: Diplom (MSc equivalent) thesis "The evolution of heterodimerising transcription factor networks." in the group of Evolutionary Bioinformatics in Muenster under the supervision of Amelie Veron and Erich Bornberg-Bauer.
  • June 2010: research stay in Prof Hue Sun Chan's lab, University of Toronto
  • 2008 - 2012: PhD project "The resolution of adaptive conflicts in protein evolution through shifts in thermodynamic stability and gene duplication"
  • April 2012 -- March 2013: working with Juliette de Meaux at the IEB in Münster  on miRNA in plants
Conferences and workshops attended
Technical skills:
  • Programming: Java, Python, Linux bash
  • Structural Bioinformatics: FoldX, Rosetta, PyMol, Chimera, PDB, CATH, python scripting
  • Bioinformatics: BLAST, sequence alignment, database search, phylogeny
  • Visualization/Illustration: Inkscape, Cinema 4D, Matplotlib (Python), Mayavi (Python), Prefuse (Java)
  • Wetlab: basic molecular biology
Teaching/course co-ordination
  • 2006-2010: teaching practicals "Bioinformatics 2 - sequence analysis" (since 2008 also course co-ordination); contents: sequence alignments, phylogenies,  protein structure prediction
  • 2009: project design and co-supervision of BSc thesis: "Testing a single-copy plasmid system for
    Protein Evolution Experiments
    " by Dieter Weber
  • Jan 2010:  BSc course "Modern Methods in Evolutionary Biology" - lecture entitled: "Structural evolution and subfunctionalisation of proteins"
  • Dec 2010: MSc research project "A mutational path connecting two proteins"
  • Feb 2011: BSc advanced project "Characterisation of the mutational energy landscape for the structural switch in Arc repressor"
Scientific social networks