bornberglab.org

Curriculum

• since 10/2022: Project manager according to the gene technology act (§ 15 GenTSV) and safety manager for laboratories at IEB
• 01/2020 - 10/2021: Safety manager for laboratories at IEB
• 08/2019 to 10/2019: Visiting Scientist at BMC Uppsala, Prof. Ylva Ivarssons' lab (EMBO short-term 8268
• 09/2018 to 10/2021: Project manager according to the gene technology act (§ 15 GenTSV)
• since 10/2016: Postdoc at the Institute for Evolution and Biodiversity, University of Muenster
• 10/2015 - 09/2016: Postdoc in the group of Prof. Dr. Frank Boeckler
• 07/2010 - 10/2015: PhD student in the group of Prof. Dr. Frank Boeckler, Molecular Design & Pharm. Biophysics, Eberhard-Karls-University Tuebingen; Title: "Using Theoretical and Biophysical Techniques to Study the Applicability of Halogen Bonds in Molecular Design"
• 05/2008 - 05/2010: MSc Chemistry, Ludwig-Maximilians-University, Munich; Title: "Towards Broader Recognition of Halogen Bonds in Drug Design - Quantum Mechanical Calculations on the Interaction of Amino Acid Models with Selected Ligand Systems"
• 10/2004 - 02/2008: BSc Chemistry and Biochemistry, Ludwig-Maximilians-University, Munich

Parental leave

• 10/2023 - 10/2024: Part-time working
• 10/2022 - 11/2022: 2nd Child
• 10/2021 - 10/2022: 1st Child

Scholarships and Grants

• DFG Grant for an international conference Number 525133849: „Proteinevolutions Meeting Münster, PEMM“, Münster, 03.07.2023 - 05.07.2023
• EMBO Short-Term Fellowship Number 8268: Using proteomic phage display to characterize the functionality of de novo genes from Drosophila melanogaster

Research Interests

• Structure prediction of de novo proteins (Alphafold, MD)
• Purification and characterization of de novo proteins (structure and function)
• Structural investigation of proteins through CD, NMR,
• Theoretical and experimental study of protein-protein (PhageDisplay, together with Ivarsson lab, Uppsala)

Publications

• Aubel, M, Eicholt, LA, Bornberg-Bauer, E, Lange, A. Wie de novo entstandene Proteine im Labor exprimiert werden können. Biospektrum. 2023; https://www.biospektrum.de/magazinartikel/wie-de-novo-entstandene-proteine-im-labor-exprimiert-werden-koennen?dl=1
• Heames, B, Buchel, F, Aubel, M, Tretyachenko, V, Loginov, D, Novák, P, Lange, A, Bornberg-Bauer, E & Hlouchová, K. Experimental characterization of de novo proteins and their unevolved random-sequence counterparts, Nature Ecology & Evolution, 7, (2023), https://doi.org/10.1038/s41559-023-02010-2
• Eicholt, LA, Aubel, M, Berk, K, Bornberg-Bauer, E, Lange, A. Heterologous expression of naturally evolved putative de novo proteins with chaperones. Protein Science. 2022; 31( 8):e4371. https://doi.org/10.1002/pro.4371
• Structural and functional characterization of a putative de novo evolved gene essential for male fertility in Drosophila Lange A. , Patel PH, Heames B, Damry, A, Saenger, T, Jackson, CJ, Findlay GD, Bornberg-Bauer E Nat Comm, 2021:12(1667), https://doi.org/10.1038/s41467-021-21667-6
• Structure and Function of Naturally Evolved de novo Proteins Bornberg-Bauer, E, Hlouchova, K, Lange A COSB, 2021, https://doi.org/10.1016/j.sbi.2020.11.010
• Small Molecule Intervention at the Dimerization Interface of Survivin by Novel Rigidized Scaffolds Tamer Ibrahim, Christoph Ernst, Andreas Lange, Susanne Hennig, Frank M. Boeckler, Drug Design, Development and Therapy, 2019:13 4247–4263
• Scaffold Effects on Halogen Bonding Strength Andreas Lange, Johannes Heidrich, Markus O. Zimmermann, Thomas E. Exner, Frank M. Boeckler J. Chem. Inf. Model., 2019, 59 (2), pp 885–894
• Tri- and Tetra-substituted Pyridinylimidazoles as Covalent Inhibitors of c-Jun N-Terminal Kinase 3 Felix Muth*, Ahmed El-Gokha*, Francesco Ansideri, Michael Eitel, Eva Döring, Adrian Sievers-Engler, Andreas Lange, Frank M. Boeckler, Michael Laemmerhofer, Pierre Koch, and Stefan A. Laufer J. Med. Chem, 2017, 60 (2), pp 594–607
• Using Surface Scans for the Evaluation of Halogen Bonds toward the Side Chains of Aspartate, Asparagine, Glutamate, and Glutamine Markus O. Zimmermann, Andreas Lange, Stefan Zahn, Thomas E. Exner & Frank M. Boeckler J. Chem. Inf. Model., 2016, 56 (7), pp 1373–1383
• Fluorescence polarization-based assays for detecting compounds binding to inactive JNK3 and p38alpha MAP kinase Francesco Ansideri, Andreas Lange, Ahmed El-Gokha, Frank M. Boeckler & Pierre Koch Anal. Biochem., 2016, 503, pp 28 - 40
• Targeting the Gatekeeper MET146 of C-Jun N-terminal Kinase 3 (JNK3) Induces a Bivalent Halogen / Chalcogen Bond Andreas Lange*, Marcel B. Guenther*, Felix M. Büttner, Markus O. Zimmermann , Johannes Heidrich, Susanne Hennig, Stefan Zahn, Christoph Schall, Adrian Sievers-Engler, Francesco Ansideri, Pierre Koch, Michael Laemmerhofer, Thilo Stehle, Stefan A. Laufer & Frank M. Boeckler J. Am. Chem. Soc., 2015, 137 (46), pp 14640–14652
• Evaluating the Potential of Halogen Bonding in Molecular Design: Automated Scaffold Decoration Using the New Scoring Function XBScore Markus O. Zimmermann, Andreas Lange, and Frank Michael Boeckler J. Chem. Inf. Model, 2015, 55 (3), pp 687–699
• Halogen-enriched fragment libraries as chemical probes for harnessing halogen bonding in fragment-based lead discovery Markus O. Zimmermann*, Andreas Lange*, Rainer Wilcken*, Markus B. Cieslik, Thomas E. Exner, Andreas C. Joerger, Pierre Koch, Frank M Boeckler Fut. Med. Chem., 2014, 6 (6), pp 617-639 (Perspective)
• Machine Learning Estimates of Natural Product Conformational Energies Matthias Rupp, Matthias R. Bauer, Rainer Wilcken, Andreas Lange, Michael Reutlinger, Frank M. Boeckler, Gisbert Schneider PLOS Computational Biology, 2014, 10 (1)
• Targeting histidine sidechains in molecular design through nitrogen-halogen bonds Andreas Lange, Markus O. Zimmermann, Rainer Wilcken, Stefan Zahn and Frank M. Boeckler J. Chem. Inf. Model., 2013, 53 (12), pp 3178–3189
• Principles and Applications of Halogen Bonding in Medicinal Chemistry and Chemical Biology Rainer Wilcken*, Markus O. Zimmermann*, Andreas Lange*, Andreas C. Joerger and Frank M. Boeckler J. Med. Chem., 2013, 56 (4), pp 1363–1388 (Perspective)
• Using halogen bonds to address the protein backbone: a systematic evaluation Rainer Wilcken, Markus O. Zimmermann, Andreas Lange, Stefan Zahn, Frank M. Boeckler J Comput Aided Mol Des, 2012, 26 (8), pp 935 - 945
• Addressing Methionine in Molecular Design through Directed Sulfur–Halogen Bonds Rainer Wilcken, Markus O. Zimmermann, Andreas Lange, Stefan Zahn, Barbara Kirchner, Frank M. Boeckler J. Chem. Theory Comput., 2011, 7 (7), pp 2307–2315

*authors contributed equally