Margaux Aubel


PhD Student




Email: m.aubel@uni-muenster.de

Tel.: +49-(0)251-83-21633

Room: 100.19

ORCID: 0000-0003-1653-9441

Twitter: @AubelMargaux

Curriculum

  • 04/2023 - 05/2023: Research stay in the group of Dr. Klara Hlouchova, University of Prague, Czech Republic
  • 05/2022 - 10/2022: Research stay in the group of Dr. Klara Hlouchova, University of Prague, Czech Republic
  • 12/2021 - present: MGSE student representative
  • 10/2021 - 12/2021: Research stay in the group of Dr. Klara Hlouchova, University of Prague, Czech Republic
  • 2021 - present: PhD student in the Molecular Evolution and Bioinformatics Group, Institute for Evolution and Biodiversity, University of Münster, Germany
  • 01/2019 - 04/2019: Internship in the group of Prof. Dr. Colin Jackson, Research School of Chemistry, Australian National University, Canberra, Australia
  • 2017 - 2020: M.Sc. in Biotechnology, University of Münster, Germany
    Thesis: Discovering novel proteins: Epistasis and de-novo emergence
  • 08/2016 - 01/2017: Erasmsus in University of Turku, Finland
  • 2014 - 2017: B.Sc. in Biosciences, University of Münster, Germany
    Thesis: Evolution-inspired protein engineering and design: Learning from the evolutionary history of enzymes

Grants and Prizes

Research interests

  • De novo protein evolution
  • Ancestral Reconstruction

Publications

  • Aubel, M, Buchel, F, Heames, B, Jones, A, Honc, O, Bornberg-Bauer, E & Hlouchová, K. High-throughput selection of human de novo-emerged sORFs with high folding potential. 2024; BioRxiv
  • Makova, K et al. The Complete Sequence and Comparative Analysis of Ape Sex Chromosomes. 2024; BioRxiv
  • Aubel, M, Eicholt, LA, Bornberg-Bauer, E, Lange, A. Wie de novo entstandene Proteine im Labor exprimiert werden können. Biospektrum. 2023; https://www.biospektrum.de/magazinartikel/wie-de-novo-entstandene-proteine-im-labor-exprimiert-werden-koennen?dl=1
  • Heames, B, Buchel, F, Aubel, M, Tretyachenko, V, Loginov, D, Novák, P, Lange, A, Bornberg-Bauer, E & Hlouchová, K. Experimental characterization of de novo proteins and their unevolved random-sequence counterparts, Nature Ecology & Evolution, (2023), https://doi.org/10.1038/s41559-023-02010-2
  • Aubel, M, Eicholt, L, Bornberg-Bauer, E. Assessing structure and disorder prediction tools for de novo emerged proteins in the age of machine learning. F1000Research 2023, 12:347. https://doi.org/10.12688/f1000research.130443.1
  • Aubel, M, Bornberg-Bauer, E. Introducing creative destruction as a mechanism in protein evolution. Proceedings of the National Academy of Sciences. 2023; 120 (6) e2220460120. https://doi.org/10.1073/pnas.2220460120
  • Eicholt, LA, Aubel, M, Berk, K, Bornberg-Bauer, E, Lange, A. Heterologous expression of naturally evolved putative de novo proteins with chaperones. Protein Science. 2022; 31( 8):e4371. https://doi.org/10.1002/pro.4371