bornberglab.org

Curriculum

• 07/2024 - present: Postdoctoral Research Associate in the Molecular Evolution and Bioinformatics Group, Institute for Evolution and Biodiversity, University of Münster, Germany
• 04/2023 - 05/2023: Research stay in the group of Dr. Klara Hlouchova, University of Prague, Czech Republic
• 05/2022 - 10/2022: Research stay in the group of Dr. Klara Hlouchova, University of Prague, Czech Republic
• 12/2021 - 2024: MGSE student representative
• 10/2021 - 12/2021: Research stay in the group of Dr. Klara Hlouchova, University of Prague, Czech Republic
• 01/2021 - 06/2024: PhD student in the Molecular Evolution and Bioinformatics Group, Institute for Evolution and Biodiversity, University of Münster, Germany
• 01/2019 - 04/2019: Internship in the group of Prof. Dr. Colin Jackson, Research School of Chemistry, Australian National University, Canberra, Australia
• 2017 - 2020: M.Sc. in Biotechnology, University of Münster, Germany
  Thesis: Discovering novel proteins: Epistasis and de-novo emergence
• 08/2016 - 01/2017: Erasmsus in University of Turku, Finland
• 2014 - 2017: B.Sc. in Biosciences, University of Münster, Germany
  Thesis: Evolution-inspired protein engineering and design: Learning from the evolutionary history of enzymes

Grants and Prizes

• SMBE graduate students excellence award 2023
• Santander Mobilitätsfond research visit funding
• Erasmus+ for internships
• DAAD research scholarship for doctoral students

Research interests

• De novo protein evolution
• Ancestral Reconstruction

Publications

Makova, K et al. The Complete Sequence and Comparative Analysis of Ape Sex Chromosomes, Nature, 2024; https://doi.org/10.1038/s41586-024-07473-2

Aubel, M, Buchel, F, Heames, B, Jones, A, Honc, O, Bornberg-Bauer, E & Hlouchová, K. High-throughput selection of human de novo-emerged sORFs with high folding potential, Genome Biology and Evolution, 2024; https://doi.org/10.1093/gbe/evae069

Aubel, M, Eicholt, LA, Bornberg-Bauer, E, Lange, A. Wie de novo entstandene Proteine im Labor exprimiert werden können. Biospektrum. 2023; https://www.biospektrum.de/magazinartikel/wie-de-novo-entstandene-proteine-im-labor-exprimiert-werden-koennen?dl=1

Heames, B, Buchel, F, Aubel, M, Tretyachenko, V, Loginov, D, Novák, P, Lange, A, Bornberg-Bauer, E & Hlouchová, K. Experimental characterization of de novo proteins and their unevolved random-sequence counterparts, Nature Ecology & Evolution, 2023, https://doi.org/10.1038/s41559-023-02010-2

Aubel, M, Eicholt, L, Bornberg-Bauer, E. Assessing structure and disorder prediction tools for de novo emerged proteins in the age of machine learning. F1000Research 2023, 12:347. https://doi.org/10.12688/f1000research.130443.1

Aubel, M, Bornberg-Bauer, E. Introducing creative destruction as a mechanism in protein evolution. Proceedings of the National Academy of Sciences. 2023; 120 (6) e2220460120. https://doi.org/10.1073/pnas.2220460120

Eicholt, LA, Aubel, M, Berk, K, Bornberg-Bauer, E, Lange, A. Heterologous expression of naturally evolved putative de novo proteins with chaperones. Protein Science. 2022; 31( 8):e4371. https://doi.org/10.1002/pro.4371