Projects
Click on the link to learn more about the projects. The classifications of the projects (Forschungsmodul, summerschool, BSc-thesis and MSc-thesis) are suggestive. If a project interests you for a Forschungsmodul but has a MSc-thesis classification, you are still strongly encouraged to contact the relevant supervisor to discuss the project.
Open Projects
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- Comparison of two methods to detect de novo genes
- Supervisor: Marie Lebherz
- Project type: FM
- Comparison of two methods to detect de novo genes
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- Annotation and basic analyses of beetle genomes
- Supervisor: Sarah Rinke
- Project type: FM
- Annotation and basic analyses of beetle genomes
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- How differences in genome annotation affect downstream analyses
- Supervisor: Sarah Rinke
- Project type: BA/FM/MA
- How differences in genome annotation affect downstream analyses
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- A quest for the missing piece in the puzzle of epithelial junctions
- Supervisor: Erich Bornberg-Bauer and Prof. Stefan Luschnig (Institute of Neuro- and Behavioural Biology)
- Project type: FM/BSc-thesis
- A quest for the missing piece in the puzzle of epithelial junctions
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- Developing algorithms for the analysis of domains and their arrangements
- Supervisor: Carsten Kemena
- Project type: BSc/Msc-thesis
- Developing algorithms for the analysis of domains and their arrangements
Ongoing Projects
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- Comparison of TE content and distribution between Drosophila species
- Supervisor: Marie Lebherz
- Project type: FM
- Comparison of TE content and distribution between Drosophila species
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- In silico evolution of newly emerging proteins
- Supervisor: Bharat Ravi
- Project type: MA/FM
- In silico evolution of newly emerging proteins
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- Finding evidence of de novo proteins using mass spectrometry data analysis
- Supervisor: Bharat Ravi
- Project type: BA/FM
- Finding evidence of de novo proteins using mass spectrometry data analysis
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- Laboratory Evolution of de novo proteins
- Supervisor: Bharat Ravi
- Project type: MA/FM
- Laboratory Evolution of de novo proteins
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- Understanding the cellular fitness effects of de novo and random proteins
- Supervisor: Bharat Ravi
- Project type: BA/FM
- Understanding the cellular fitness effects of de novo and random proteins
Previous Projects
- Improve a de novo TE library
- Supervisor: Marie Lebherz
- Project type: FM
- In silico selection and directed evolution of bioactive de novo emerged proteins
- Supervisor: Lars Eicholt
- Project type: BA/FM/MA
- Purification of putative de novo proteins from inclusion bodies
- Supervisor: Andreas Lange
- Project type: FM
- Ancestral reconstruction – Characterization of ancestral proteins of a possible de novo protein from Homo sapiens
- Supervisor: Andreas Lange
- Project type: BA/FM
- Genome assembly of Drosophila melanogaster
- Supervisor: Anna Grandchamp
- Project type: FoM/BSc/MSc
- Studying the way of emergence of the de novo genes in Drosophila melanogaster
- Supervisor: Anna Grandchamp
- Project type: FoM/BSc/MSc
- Chemosensory genes and mate perception in the viviparous cockroach /Diploptera punctata/
- Supervisor: Bertrand Fouks
- Project type: FoM / BSc
- Regulation of Gene Expression & Transposable Elements
- Supervisor: Bertrand Fouks
- Project type: FM
- Sociality Impact on Genome Evolution
- Supervisor: Bertrand Fouks
- Project type: FM/ BSc/ MSc-thesis
- Transposable Elements families & Functional Categories
- Supervisor: Bertrand Fouks
- Project type: FM
- Sequencing Techniques & the Discovery of Transposable Elements
- Supervisor: Bertrand Fouks
- Project type: FM/ BSc/ MSc-thesis
- Purification and analysis (in vitro & in silico) of putative de novo proteins
- Supervisor: Lars Eicholt
- Project type: BA/FM/MA
- Expression, purification, analysis of putative de novo proteins
- Supervisor: Margaux Aubel & Lars Eicholt
- Project type: BA/FM/MA
- Role of phase separation in the activity of de novo proteins
- Supervisor: Lars Eicholt
- Project type: BA/FM
- Using AlphaFold2 to identify promising de novo protein candidates
- Supervisor: Lars Eicholt
- Project type: MA
- Improving RADIANT
- Supervisor: Carsten Kemena
- Project type: BSc/Msc-thesis
- Implementing porthoDom
- Supervisor: Carsten Kemena
- Project type: BSc
- Genome annotation of slave-maker ants and their hosts for comparative analyses
- Supervisor: Alice Séguret
- Project type: MSc thesis
- Development of a high-throughput assay to identify possible foldable de novo proteins
- Supervisor: Margaux Aubel & Lars Eicholt
- Project type: BA/FM
- Chaperones – The holy grail for soluble expression of de novo proteins from D. melanogaster in E.coli? (lab-based)
- Supervisor: Andreas Lange
- Project type: FM/BSc/MSc-thesis (students welcome)
- Adaptive Laboratory Evolution: Mapping Epistatic Mutations Within Ancestral Sulfatases
- Supervisor: Berndjan Eenink
- Project type: FoM/BSc-thesis
- Adaptive Laboratory Evolution: Disentangling and Combining Mutations to Reveal Epistatic Effects
- Supervisor: Bert van Loo
- Project type: FoM/BSc/MSc-thesis
- Identifying the transcriptional regulators of two insulin peptides, important in the development of termite queens.
- Supervisor: Mark Harrison/Alice Séguret
- Project type: FM/BSc/MSc-thesis
- Does methylation target transposable elements in the termite Macrotermes natalensis?
- Supervisor: Alice Séguret/Mark Harrison
- Project type: FM
- The evolution of gene network properties during slavemaker evolution
- Supervisor: Alice Séguret
- Project type: FM
- The potential role of repeats in the evolution of slave-making
- Supervisor: Alice Séguret
- Project type: FM
- Immunity gene family evolution in the European Beewolf
- Supervisor: Evelien Jongepier
- Project type: MSc project
- Historical Enzyme Evolution: Emergence of Sulfatases in the Metallo-β-Lactamase Superfamily
- Supervisor: Bert van Loo
- Project type: FoM/BSc/MSc-thesis
- Reading frame extension as potential domain emergence mechanism
- Supervisors: Andreas Lange/Brennen Haemes
- Project type: MSc-thesis
- Evolution of RNA structure.
- Supervisor: Jasmin Kurafeiski
- Project type: FM/BSc/MSc
- Effects of Epistasis on Transcription Factor Binding
- Supervisor: Jasmin Kurafeiski
- Project type: Summer School Project
- Comparative analysis of chemoreceptors in cockroaches
- Supervisor: Mark Harrison
- Project type: MSc-thesis
- Inference of C- and N-terminus protein extensions
- Supervisor: April Kleppe
- Project type: BSc-thesis
- Evolution-Inspired Protein Engineering and Design: Learning from the Evolutionary History of Haloalcohol Dehalogenases?Comparative analysis of chemoreceptors in cockroaches
- Supervisor: Bert van Loo
- Project type: BSc-thesis
- Evolution-Inspired Protein Engineering and Design: the Effect of Selection Pressure on Secondary Activities
- Supervisor: Bert van Loo
- Project type: FoM/BSc/MSc-thesis
- Investigating proto-genic ORFs
- Supervisor: Brennen Heames
- Project type: Forschungsmodul
- Creating a Benchmark for RADS
- Supervisor: Carsten Kemena
- Project type: BSc-thesis
- Fast domain annotation
- Supervisor: Carsten Kemena
- Project type: Forschungsmodul
- New Proteins out of Thin Air?
- Supervisor: Jonathan Schmitz
- Project type: BSc-thesis
- Evolutionary rate of novel genes
- Supervisor: Jonathan Schmitz
- Project type: Forschungsmodul
- Evolution-Inspired Protein Engineering and Design: Learning from the Evolutionary History of Haloalkane Dehalogenases?
- Supervisor: Bert van Loo
- Project type: BSc-thesis
- Identifying regulatory elements associated with de novo genes
- Supervisor: Brennen Heames
- Project type: Summer School Project
- Genomic adaptations in the Wolbachia endosymbiont of the European beewolf
- Supervisor: Evelien Jongepier
- Project type: Forschungsmodule
- The genomics of enemy recognition in the slaves of slavemaker ants
- Supervisor: Evelien Jongepier
- Project type: MSc
- Domain-Exon Overlap
- Supervisor: Carsten Kemena
- Project type: Forschungsmodule
- Partial Domain inclusion into Dogma
- Supervisor: Carsten Kemena
- Project type: Forschungsmodule
- Are de novo genes real? Characterization of possible de novo drosophila genes (lab-based)
- Supervisor: Andreas Lange
- Project type: FM/BSc/MSc-thesis
- Finding de novo genes in human populations
- Supervisor: Daniel Dowling
- Project type: Forschungsmodule
- Testing the evolutionary theory of ageing on eusocial insects
- Supervisor: Mark Harrison
- Project type: FM/MSc-thesis
- Atlas – a de novo gene important for spermatogenesis in male Drosophila melanogaster? (lab-based)
- Supervisor: Andreas Lange
- Project type: FM/BSc
- Conservation analysis of protein domain arrangements
- Supervisor: Carsten Kemena
- Project type: FM