Curriculum

• 2026 – present: Postdoctoral Research Associate in the Molecular Evolution and Bioinformatics Group, Institute for Evolution and Biodiversity, University of Münster, Germany, Prof. Erich Bornberg-Bauer (Supervisor)

• 2025 – 2026: Postdoctoral Research Associate in the Viral and Microbial Proteins Group, Institute of Organic Chemistry and Biochemistry, Prague, Czech Republic, Dr. Iva Pichova (Supervisor)

• 2019 – 2024: PhD: “Evolution of the communication system in insect”, Institute of Organic Chemistry and Biochemistry, Prague, Czech Republic, Dr. Iva Pichova (Supervisor)

• 2017 – 2019: M.Sc. in General and Applied Biochemistry, University of Chemistry and Technology in Prague, Czech Republic

• 2016 – 2017: Research internship (Erasmus +) in Cell- and Molecular Biology, Friedrich-Alexander University, Erlangen, Germany

• 2013 – 2016: B.Sc. In Biochemistry and Biotechnology, University of Chemistry and Technology in Prague, Czech Republic

Research Interest

Protein Evolution, Protein Structure, Reduced Amino Acid Alphabets, Structural Biology, Protein Engineering

Publications

Dostál, Uhrová, Škrlová, Macháček, Clarová, Lepšík, Bulvas, Vrábel, Heidingsfeld, Pichová

(2025). Structural characterization and inhibition of carbonic anhydrase from Candida

parapsilosis. Journal of Structural Biology: X, 100140, 2590-1524.

https://doi.org/10.1016/j.yjsbx.2025.100140.

Macháček, Tupec, Horáček, Halmová, Roy, Machara, Kyjaková, Lukšan, Pichová & Hanus

(2023). Evolution of linoleic acid biosynthesis paved the way for ecological success of termites.

Molecular Biology and Evolution, 40(4). https://doi.org/10.1093/molbev/msad087

Tupec, Culka, Machara, Macháček, Bím, Svatoš, Rulíšek & Pichová (2022). Understanding

desaturation/hydroxylation activity of castor stearoyl Δ9-Desaturase through rational

mutagenesis. Computational and Structural Biotechnology Journal, 20, 1378–1388.

https://doi.org/10.1016/j.csbj.2022.03.010

Dostál, Brynda, Blaha, Macháček, Heidingsfeld & Pichová (2018). Crystal structure of

carbonic anhydrase CaNce103p from the pathogenic yeast Candida albicans. BMC Structural

Biology, 18(1). https://doi.org/10.1186/s12900-018-0093-4