bornberglab.org

Curriculum

Research Interests

• Protein Repeats (P2)
• Protein Engineering (P1)
• Modular Protein Evolution (P2)
• Role of Pressure in Protein Structure and Function
• Evolution of Ant Venoms (G1)

Selected Publications

• Felício, Martins, Alves, Amorim, Macedo‐Ribeiro, & Merski “Evolutionary model of repeat insertions in Ataxin-3 traces the origin of the polyglutamine stretch to an ancestral ubiquitin binding module”,
  Protein Science, vol. 33, e5236, 2024
• Merski, Macedo-Ribeiro, Wieczorek, & Górna “The repeating, modular architecture of the HtrA proteases”,
  Biomolecules, vol. 12, 793, 2022
• Blanco, Stafford, Lavoie, Brandenburg, Górna, & Merski “A simple model for the total number of SARS-CoV-2 infections on a national level”,
  Epidemiology and Infection, vol. 149, e80, 2021
• Merski, Skrzeczkowski, Roth, & Górna “A geometric definition of short to medium range hydrogen-mediated interactions in proteins”,
  Molecules, vol. 25, 5326, 2020
• Merski, Mlynarczyk, Ludwiczak, Skrzeczkowski, Dunin-Horkawicz, & Górna, “Self-analysis of repeat proteins reveals evolutionarily conserved patterns”,
  BMC Bioinformatics, vol. 21, 179, 2020
• Merski, Moreira, Abreu, Ramos, Fernandes, Martins, Pereira, & Macedo-Ribeiro “Molecular motion regulates the activity of the mitochondrial serine protease HtrA2”,
  Cell Death & Disease, vol. 8, e3119, 2017
• Merski, Fischer, Balius, Eidam, & Shoichet “Homologous ligands accommodated by discrete conformations of a buried cavity”,
  PNAS (USA), vol. 112, 5039, 2015
• Merski & Shoichet “Engineering a model protein cavity to catalyze the Kemp elimination”,
  PNAS (USA) vol. 109, 16179, 2012